| 1 | Pz Cussons Ghana PLC | Ghana | Accra | Sanyo Road | Greater Accra | N/A | N/A | 2002 | $15,841,913,395 | 360 | Corporation | 58 | C-877 |
| 2 | Vehrad Transport And Haulage Company LIMITED | Ghana | Tema | Community 4 Cocoa Processing Factory, Sanyo Road | Greater Accra | N/A | N/A | 2016 | $10,301,133,251 | 100 | Corporation | N/A | CS024392016 |
| 3 | Mechanical Lloyd PLC | Ghana | Accra | Adjacent Stic, No.2 Adjuma Crescent | Greater Accra | N/A | N/A | 2020 | $3,667,544,087 | 22 | Corporation | N/A | C4447 |
| 4 | Ghana Cocoa Board | Ghana | Accra | Cocoa House 41 Kwame Nkrumah Avenue | Greater Accra | N/A | N/A | 2021 | $2,271,848,628 | 800 | Government body | 212 | P.N.D.CL. 81 |
| 5 | Resitech LIMITED | Ghana | Accra | Opposite Telecom University , Unnumbered Building Nsawam R | Greater Accra | N/A | N/A | 2018 | $1,980,637,290 | 14 | Corporation | N/A | CS211732018 |
| 6 | Tullow Ghana LIMITED | Ghana | Accra | Motorway Extension, Off George Bush Highway | Greater Accra | N/A | N/A | 2013 | $1,634,100,000 | 351 | | 43 | ET002082013 |
| 7 | Electricity Company Of Ghana LIMITED | Ghana | Accra | Ministries, Electro-volta House 28th February Road | Greater Accra | N/A | N/A | 2025 | $1,317,880,025 | 6,441 | Corporation | 212 | CS761772015 |
| 8 | Commerce Trade General & Products Marketing CO LTD | Ghana | Kasoa | Plot No.4026-4026 West Africa Trade & Business Center | Central | N/A | N/A | 2009 | $1,120,520,050 | 2,782 | Corporation | N/A | CA-56872 |
| 9 | Scancom PLC | Ghana | Accra | Mtn House Independence Avenue | Greater Accra | N/A | N/A | 2023 | $873,121,523 | 1,385 | Corporation | 2 | PL000322016 |
| 10 | Max Lambda Company LIMITED | Ghana | Accra | Challenge House 6 Ashakle Street | Greater Accra | N/A | N/A | 2018 | $800,000,000 | 9 | Corporation | N/A | CS035842018 |
| 11 | Tacoa Constructions Company LIMITED | Ghana | Accra | The World Trade Centre Convention Centre Independence Avenue | Greater Accra | N/A | N/A | 2020 | $681,450,840 | 200 | Corporation | N/A | CS343552014 |
| 12 | Dahzah Brand Ghana LIMITED | Ghana | Accra | House Number B114717, Near Odonti Street, Ga-310-7619 | Greater Accra | N/A | N/A | 2020 | $680,000,000 | 12 | Corporation | N/A | CS061782020 |
| 13 | Goil PLC | Ghana | Accra | Near Sic Life Head Office, Goil House Kojo Thompson Road on the | Greater Accra | N/A | N/A | 2023 | $677,796,865 | 2,130 | Corporation | N/A | CS352862014 |
| 14 | Volta River Authority | Ghana | Accra | Near Independence Square, Electro-volta House 28th February Min | Greater Accra | N/A | N/A | 2018 | $663,672,255 | 1,084 | Local government body | 10 | N/A |
| 15 | Newmont Golden Ridge LIMITED | Ghana | Accra | Standard Chartered Bank (scb), Head Office Building 87 Independe | N/A | N/A | N/A | 2017 | $574,207,000 | 1,025 | Corporation | 205 | CS304352017 |
| 16 | Scancom PLC | Ghana | Accra | Mtn House Independence Avenue | Greater Accra | N/A | N/A | 2023 | $548,585,963 | 1,385 | Corporation | N/A | PL000322016 |
| 17 | B 5 Plus LIMITED | Ghana | Tema | Aflao Road | Greater Accra | N/A | N/A | 2013 | $507,627,344 | 1,050 | Corporation | 2 | CS325652013 |
| 18 | Total Energies Ghana | Ghana | Accra | Total Energies House, 25 Liberia Road | Greater Accra | N/A | N/A | N/A | $505,434,167 | 150 | | N/A | N/A |
| 19 | Total Petroleum Ghana LIMITED | Ghana | Accra | Total House, P.o.box 553 25, Near South Liberia Road | Greater Accra | N/A | N/A | 2006 | $505,434,167 | 74 | Corporation | N/A | N/A |
| 20 | Agate Nenyo | Ghana | Agate | David Tefe Street- Jhs Premises Kpodzi | N/A | N/A | N/A | N/A | $461,475,000 | 5,000 | Non profit organization | N/A | N/A |
| 21 | Totalenergies Marketing Ghana PLC | Ghana | Accra | Total House 25 Liberia Road | Greater Accra | N/A | N/A | 2023 | $448,019,033 | 214 | Corporation | 5329 | N/A |
| 22 | Asante Gold CORPORATION | Ghana | Accra | Jungle Avenue | Greater Accra | N/A | N/A | N/A | $433,954,292 | 25 | Corporation | 2 | N/A |
| 23 | Ghana Railways CO LIMITED | Ghana | Sekondi-takoradi | Western Region, Railway Offices | Western | N/A | N/A | 2001 | $364,784,000 | 4,000 | Government body | N/A | C-94,198 |
| 24 | Bank Of Ghana | Ghana | Accra | Bank of Ghana Building One Thorpe Road | Greater Accra | 2674 | N/A | 2016 | $346,402,602 | 2,206 | Corporation | 212 | N/A |
| 25 | E.s.l.a. PLC | Ghana | Accra | Ground Floor Ocean House 13 | Greater Accra | N/A | N/A | N/A | $304,572,175 | 1,000 | Corporation | N/A | N/A |