| 1 | Astrazeneca PLC | Unitedkingdom | Chesterton | 1 Francis Crick Avenue | Cambridgeshire | CB2 0AA | astrazeneca.***** | 1999 | $54,073,000,000 | 92,900 | N/A | N/A | N/A |
| 2 | Gsk PLC | Unitedkingdom | Saint Giles | 79 New Oxford Street | London | WC1A 1DG | uk.***** | 1999 | $39,774,790,432 | 69,305 | N/A | N/A | N/A |
| 3 | Haleon PLC | Unitedkingdom | Weybridge | The Heights Building 5 First Floor | Surrey | KT13 0NY | N/A | 2021 | $14,239,871,906 | 24,000 | N/A | N/A | N/A |
| 4 | Sdc Technologies INC. | Unitedkingdom | Cwmbran | Unit 7, Avondale Industrial Estate | Torfaen | NP44 1UG | sdctech.***** | 1995 | $14,044,899,792 | 9 | N/A | N/A | N/A |
| 5 | Ucb Celltech | Unitedkingdom | Slough | 216 Bath Road | Slough | SL1 4EN | N/A | 2006 | $3,422,370,755 | 1,411 | N/A | N/A | N/A |
| 6 | Hikma Pharmaceuticals Public LIMITED Company | Unitedkingdom | Marylebone | 1 New Burlington Place | London | W1S 2HR | hikma.***** | 2005 | $3,127,000,000 | 9,308 | N/A | N/A | N/A |
| 7 | Inovyn Europe LIMITED | Unitedkingdom | Runcorn | Bankes Lane | Halton | WA7 4EL | N/A | 2016 | $3,051,756,586 | 442 | N/A | N/A | N/A |
| 8 | Life Technologies LIMITED | Unitedkingdom | Southbar | 3 Fountain Drive | Renfrewshire | PA4 9RF | lifetechnologies.***** | 1983 | $2,330,182,811 | 1,625 | N/A | N/A | N/A |
| 9 | Tate & Lyle Public LIMITED Company | Unitedkingdom | Saint Giles | 1 Kingsway | London | WC2B 6AT | tateandlyle.***** | 1903 | $2,196,013,960 | 3,912 | N/A | N/A | N/A |
| 10 | Air Products Equipment LIMITED | Unitedkingdom | Chertsey | Samsung House | Surrey | KT16 0PS | N/A | 2020 | $1,697,794,000 | 242 | N/A | N/A | N/A |
| 11 | Roche Products LIMITED | Unitedkingdom | Water End | Unit 6 | Hertfordshire | AL7 1TW | rocheuk.***** | 1908 | $1,423,143,336 | 1,505 | N/A | N/A | N/A |
| 12 | Glaxosmithkline International LIMITED | Unitedkingdom | Saint Giles | 79 New Oxford Street | London | WC1A 1DG | gsk.***** | 1988 | $1,405,331,375 | 4,000 | N/A | N/A | N/A |
| 13 | Reckitt Benckiser Corporate Services LIMITED | Unitedkingdom | Slough | 103-105 Bath Road | Slough | SL1 3UH | reckitt.***** | 2000 | $1,352,411,330 | 1,586 | N/A | N/A | N/A |
| 14 | Mcbride PLC | Unitedkingdom | Benchill | Arbeta | Manchester, Greater Manchester | M40 5BP | mcbride.***** | 1927 | $1,188,773,942 | 3,062 | N/A | N/A | N/A |
| 15 | Indivior PLC | Unitedkingdom | Slough | 234 Bath Road | Slough | SL1 4EE | N/A | 2014 | $1,188,000,000 | 1,152 | N/A | N/A | N/A |
| 16 | Synthomer Trading LIMITED | Unitedkingdom | Harlow | Temple Fields | Essex | CM20 2BH | N/A | 2016 | $1,184,735,730 | 197 | N/A | N/A | N/A |
| 17 | Cmc Materials LLC | Unitedkingdom | Penarth | The Business Centre, Barry | The Vale of Glamorgan | CF63 2AW | N/A | 2000 | $1,116,270,000 | 5 | N/A | N/A | N/A |
| 18 | Patheon UK LIMITED | Unitedkingdom | Dorcan | Kingfisher Drive | Swindon | SN3 5BZ | patheon.***** | 1999 | $1,072,550,156 | 553 | N/A | N/A | N/A |
| 19 | Basf Public LIMITED Company | Unitedkingdom | Stockport | 4th and 5th Floors, 2 Stockport Exchange | Manchester, Greater Manchester | SK1 3GG | N/A | 1865 | $1,051,250,652 | 442 | N/A | N/A | N/A |
| 20 | Ineos Aromatics LIMITED | Unitedkingdom | Lyndhurst | Hawkslease, Chapel Lane | Hampshire | SO43 7FG | N/A | 1998 | $933,451,737 | 419 | N/A | N/A | N/A |
| 21 | Chevron Oronite SAS | Unitedkingdom | Windsor | 59-60 Thames Street | Windsor and Maidenhead | SL4 1TX | N/A | 1992 | $904,052,926 | 766 | N/A | N/A | N/A |
| 22 | Ipsen Biopharm LIMITED | Unitedkingdom | Wrexham | Unit 9 | Wrexham | LL13 9UF | ipsen.***** | 1981 | $837,724,831 | 713 | N/A | N/A | N/A |
| 23 | Afton Chemical LIMITED | Unitedkingdom | Bracknell | London Road | Bracknell Forest | RG12 2UW | aftonchemical.***** | 1975 | $815,528,987 | 285 | N/A | N/A | N/A |
| 24 | Janssen-Cilag LIMITED | Unitedkingdom | Booker | 50-100 Holmers Farm Way | Buckinghamshire | HP12 4EG | jj.***** | 1971 | $814,193,778 | 1,091 | N/A | N/A | N/A |
| 25 | Novartis Pharmaceuticals UK LIMITED | Unitedkingdom | Shepherd'S Bush | 2nd Floor | London | W12 7FQ | novartis.***** | 1911 | $786,373,349 | 848 | N/A | N/A | N/A |
| 26 | Certis Belchim B.V. | Unitedkingdom | Cambridge | Unit 5 | Cambridgeshire | CB21 6AD | certiseurope.***** | 2000 | $777,579,701 | 677 | N/A | N/A | N/A |
| 27 | Yara UK LIMITED | Unitedkingdom | York | Yara UK Ltd | York | YO42 1DN | yara.***** | 1905 | $768,710,956 | 237 | N/A | N/A | N/A |
| 28 | Eisai Europe LIMITED | Unitedkingdom | Hatfield | Mosquito Way | Hertfordshire | AL10 9SN | eisai.***** | 1988 | $734,244,169 | 1,352 | N/A | N/A | N/A |
| 29 | Imperial Chemical Industries LIMITED | Unitedkingdom | Wexham Court | The Akzonobel Building | Slough | SL2 5DS | akzonobel.***** | 1930 | $732,903,780 | 671 | N/A | N/A | N/A |
| 30 | Pfizer LIMITED | Unitedkingdom | Sandwich | Ramsgate Road | Kent | CT13 9NJ | pfizer.***** | 1953 | $716,555,389 | 1,243 | N/A | N/A | N/A |
| 31 | Novo Nordisk LIMITED | Unitedkingdom | Gatwick | 3 City Place | Gloucestershire | RH6 0PA | novonordisk.***** | 1973 | $707,968,705 | 694 | N/A | N/A | N/A |
| 32 | Jazz Pharmaceuticals Operations UK LIMITED | Unitedkingdom | Bobbing | Building 730 | Kent | ME9 8AG | gwpharm.***** | 1999 | $700,001,635 | 731 | N/A | N/A | N/A |
| 33 | Wellcome Trust | Unitedkingdom | Saint Johns Wood | Wellcome Trust | London | NW1 2BF | benugo.***** | 1962 | $683,754,851 | 2,314 | N/A | N/A | N/A |
| 34 | Takeda UK LIMITED | Unitedkingdom | High Wycombe | Building 3 | Buckinghamshire | HP10 0DF | takeda.***** | 1997 | $654,869,246 | 480 | N/A | N/A | N/A |
| 35 | Brenntag UK LIMITED | Unitedkingdom | West Park | Alpha House | Leeds, West Yorkshire | LS16 6QY | brenntag.***** | 1912 | $645,802,902 | 826 | N/A | N/A | N/A |
| 36 | Air Products Public LIMITED Company | Unitedkingdom | Chertsey | Samsung House | Surrey | KT16 0PS | airproducts.***** | 1909 | $613,324,065 | 1,516 | N/A | N/A | N/A |
| 37 | Bio Products Laboratory LIMITED | Unitedkingdom | Borehamwood | Dagger Lane | Hertfordshire | WD6 3BX | bpl.***** | 2010 | $600,508,000 | 1,076 | N/A | N/A | N/A |
| 38 | Eli Lilly And Company LIMITED | Unitedkingdom | Basingstoke | Eli Lilly and Co. | Hampshire | RG21 4FA | lilly.***** | 1934 | $584,287,596 | 604 | N/A | N/A | N/A |
| 39 | Teva UK LIMITED | Unitedkingdom | Castleford | Ridings Point | Wakefield, West Yorkshire | WF10 5HX | tevauk.***** | 1935 | $565,390,395 | 434 | N/A | N/A | N/A |
| 40 | Whitman Laboratories LIMITED | Unitedkingdom | Weston | Bedford Rd | Hampshire | GU32 3DD | N/A | 1966 | $557,051,000 | 350 | N/A | N/A | N/A |
| 41 | Urenco UK LIMITED | Unitedkingdom | Chester | Capenhurst Lane | Cheshire West and Chester | CH1 6ER | urenco.***** | 1993 | $525,304,603 | 584 | N/A | N/A | N/A |
| 42 | Mitsubishi Chemical UK LIMITED | Unitedkingdom | Billingham | Po Box 8 | Stockton-on-tees | TS23 1LE | hertel.***** | 1999 | $520,095,150 | 535 | N/A | N/A | N/A |
| 43 | Aventis Pharma LIMITED | Unitedkingdom | Eastheath | 410 Thames Valley Park Drive | Wokingham | RG6 1PT | sanofi.***** | 1980 | $495,811,900 | 666 | N/A | N/A | N/A |
| 44 | Sherwin-Williams UK LIMITED | Unitedkingdom | Sarsden | Avenue One | Oxfordshire | OX28 4XR | sherwinwilliams.***** | 1992 | $493,732,646 | 1,033 | N/A | N/A | N/A |
| 45 | Innospec LIMITED | Unitedkingdom | Ellesmere Port | Innospec Manufacturing Park | Cheshire West and Chester | CH65 4EY | innospecinc.***** | 1938 | $470,057,018 | 636 | N/A | N/A | N/A |
| 46 | Glaxosmithkline Sl LP | Unitedkingdom | Saint Giles | 79 New Oxford Street | London | WC1A 1DG | gsk.***** | 2009 | $459,522,113 | 4,000 | N/A | N/A | N/A |
| 47 | Givaudan UK LIMITED | Unitedkingdom | Willesborough | Kennington Road | Kent | TN24 0LT | givaudan.***** | 1961 | $452,875,591 | 538 | N/A | N/A | N/A |
| 48 | Gilead Sciences Europe LTD. | Unitedkingdom | Harmondsworth | 2 Roundwood Avenue | London | UB11 1AS | gilead.***** | 2005 | $441,532,149 | 581 | N/A | N/A | N/A |
| 49 | Atnahs Pharma UK LIMITED | Unitedkingdom | Basildon | Sovereign House | Essex | SS14 3FR | N/A | 2013 | $440,285,349 | 315 | N/A | N/A | N/A |
| 50 | Ascend Performance Materials European LIMITED | Unitedkingdom | Altrincham | 1 Ashley Road | Manchester, Greater Manchester | WA14 2DT | N/A | 2018 | $436,428,144 | 1 | N/A | N/A | N/A |
| 51 | Elanco UK Ah LIMITED | Unitedkingdom | Hook | Form Two | Hampshire | RG27 9XA | elanco.***** | 2018 | $434,799,714 | 340 | N/A | N/A | N/A |
| 52 | Imcd UK LIMITED | Unitedkingdom | Sutton | I M C D UK Ltd | London | SM1 4AF | imcd.***** | 1988 | $434,584,520 | 338 | N/A | N/A | N/A |
| 53 | Boehringer Ingelheim LIMITED | Unitedkingdom | Bracknell | Ellesfield Avenue | Bracknell Forest | RG12 8YS | boehringer-ingelheim.***** | 1962 | $431,553,190 | 344 | N/A | N/A | N/A |
| 54 | Tronox Pigment UK LIMITED | Unitedkingdom | Immingham | Laporte Road | North East Lincolnshire | DN40 2PR | tronox.***** | 1997 | $419,142,573 | 359 | N/A | N/A | N/A |
| 55 | Qualasept Holdings LIMITED | Unitedkingdom | Corsham | 3 Corsham Science Park | Wiltshire | SN13 9FU | bathasu.***** | 2016 | $414,744,512 | 484 | N/A | N/A | N/A |
| 56 | Actavis Holdings UK Ii LIMITED | Unitedkingdom | Higher Slade | Whiddon Valley | Devon | EX32 8NS | cymex.***** | 1998 | $411,455,045 | 600 | N/A | N/A | N/A |
| 57 | Eisai Manufacturing LIMITED | Unitedkingdom | Hatfield | Mosquito Way | Hertfordshire | AL10 9SN | eisai.***** | 2007 | $406,719,058 | 366 | N/A | N/A | N/A |
| 58 | Ineos Acetyls UK LIMITED | Unitedkingdom | Lyndhurst | Hawkslease | Hampshire | SO43 7FG | ineos.***** | 2015 | $406,696,472 | 331 | N/A | N/A | N/A |
| 59 | Dow Chemical Company LIMITED | Unitedkingdom | Cheadle | 5 Oakwater Avenue, Cheadle Royal Business Park, , | Manchester, Greater Manchester | SK8 3SR | N/A | 1954 | $402,964,957 | 243 | N/A | N/A | N/A |
| 60 | Petroineos Manufacturing Scotland LIMITED | Unitedkingdom | Grangemouth | Po Box 21 | Falkirk | FK3 9XH | petroineos.***** | 1919 | $402,047,581 | 499 | N/A | N/A | N/A |
| 61 | Hywax GMBH | Unitedkingdom | Birkenhead | Wallasey Bridge Road | Wirral, Merseyside | CH41 1EB | sasolwax.***** | 1997 | $378,525,988 | 375 | N/A | N/A | N/A |
| 62 | Infineum UK LTD. | Unitedkingdom | Frilford | Milton Hill Business & Technology Centre | Oxfordshire | OX13 6BB | infineum.***** | 1999 | $377,980,167 | 472 | N/A | N/A | N/A |
| 63 | Biosimilars Newco LIMITED | Unitedkingdom | Saint Giles | 16 Great Queen Street Covent Garden | London | WC2B 5AH | N/A | 2022 | $371,101,000 | 8 | N/A | N/A | N/A |
| 64 | Cavendish Nuclear LIMITED | Unitedkingdom | Braunstone Town | 20 Radar Road | Leicester | LE3 1UF | cavendishnuclear.***** | 2009 | $368,958,488 | 1,557 | N/A | N/A | N/A |
| 65 | Origin UK Operations LIMITED | Unitedkingdom | Royston | 1-3 Freeman Court | Barnsley, South Yorkshire | SG8 5HW | originfertilisers.***** | 1990 | $365,999,435 | 314 | N/A | N/A | N/A |
| 66 | Venator Materials UK LIMITED | Unitedkingdom | Wynyard | Titanium House | Stockton-on-tees | TS22 5FD | venatorcorp.***** | 1964 | $363,127,648 | 573 | N/A | N/A | N/A |
| 67 | Bristol-Myers Squibb Pharmaceuticals LIMITED | Unitedkingdom | Uxbridge | Sanderson Road | London | UB8 1DH | bms.***** | 1990 | $361,829,403 | 401 | N/A | N/A | N/A |
| 68 | Ppg Architectural Coatings UK LIMITED | Unitedkingdom | Batley | Huddersfield Road | Kirklees, West Yorkshire | WF17 9XA | johnstonestrade.***** | 1947 | $361,452,439 | 1,347 | N/A | N/A | N/A |
| 69 | Argent Energy LIMITED | Unitedkingdom | London | Swire House | London | SW1E 6AJ | argentenergy.***** | 2005 | $360,246,068 | 161 | N/A | N/A | N/A |
| 70 | Shin-Etsu Handotai Europe LIMITED | Unitedkingdom | Livingston | Toll Roundabout | West Lothian | EH54 7DA | sehe.***** | 1984 | $356,451,000 | 523 | N/A | N/A | N/A |
| 71 | Laxmi Bns Holdings LIMITED | Unitedkingdom | Ruislip | Unit 4 | London | HA4 0NU | N/A | 2010 | $348,109,764 | 378 | N/A | N/A | N/A |
| 72 | Ineos Chemicals Grangemouth LIMITED | Unitedkingdom | Grangemouth | Po Box 21 | Falkirk | FK3 9XH | ineos.***** | 1919 | $346,209,786 | 596 | N/A | N/A | N/A |
| 73 | Lonza Biologics PLC | Unitedkingdom | Slough | Lonza Biologics Plc | Slough | SL1 4DX | lonza.***** | 1992 | $338,422,922 | 1,389 | N/A | N/A | N/A |
| 74 | Billions Europe LTD | Unitedkingdom | Stockton-on-tees | Winder House | Stockton-on-tees | TS18 3EX | lomonbillions.***** | 2014 | $334,318,300 | 252 | N/A | N/A | N/A |
| 75 | Omega Pharma LIMITED | Unitedkingdom | London | One Embassy Gardens | London | SW11 7BW | perrigo.***** | 1887 | $333,387,689 | 221 | N/A | N/A | N/A |
| 76 | Infineum International LIMITED | Unitedkingdom | Frilford | Milton Hill Business & Technology Park | Oxfordshire | OX13 6BD | infineum.***** | 1998 | $330,153,210 | 395 | N/A | N/A | N/A |
| 77 | Csl Behring UK LIMITED | Unitedkingdom | Haywards Heath | 4 Milton Road | West Sussex | RH16 1AH | cslbehring.***** | 1982 | $322,637,419 | 61 | N/A | N/A | N/A |
| 78 | Sigma-Aldrich Company LIMITED | Unitedkingdom | Gillingham | The Old Brickyard | Dorset | SP8 4XT | merckchem.***** | 1987 | $321,725,015 | 444 | N/A | N/A | N/A |
| 79 | Persan, S.A. | Unitedkingdom | Watford | Arliss Court | Hertfordshire | WD17 1JY | N/A | 2003 | $320,829,286 | 6 | N/A | N/A | N/A |
| 80 | Scott Bader Company LIMITED | Unitedkingdom | Strixton | Wollaston Hall, Wollaston | Northamptonshire | NN29 7FH | scottbader.***** | 1921 | $319,889,411 | 800 | N/A | N/A | N/A |
| 81 | Accord-Uk LTD | Unitedkingdom | Barnstaple | Whiddon Valley | Devon | EX32 8NS | actavis.***** | 1903 | $317,563,099 | 699 | N/A | N/A | N/A |
| 82 | Coopervision LIMITED | Unitedkingdom | Anthill Common | Delta Park | Hampshire | PO15 5RL | onebrightvision.***** | 1998 | $305,487,678 | 399 | N/A | N/A | N/A |
| 83 | Accord Healthcare LIMITED | Unitedkingdom | Harrow | Sage House | London | HA1 4HF | accord-healthcare.***** | 2008 | $304,239,012 | 463 | N/A | N/A | N/A |
| 84 | Ecolab LIMITED | Unitedkingdom | Northwich | Winnington Avenue | Cheshire West and Chester | CW8 4DX | bioquell.***** | 1960 | $302,648,409 | 967 | N/A | N/A | N/A |
| 85 | Zoetis UK LIMITED | Unitedkingdom | Leatherhead | Springfield Drive | Surrey | KT22 7LP | zoetis.***** | 2012 | $301,349,656 | 229 | N/A | N/A | N/A |
| 86 | Abcam LIMITED | Unitedkingdom | Cambridge | Abcam Plc | Cambridgeshire | CB2 0AX | abcam.***** | 1998 | $299,172,952 | 635 | N/A | N/A | N/A |
| 87 | Cf Fertilisers UK LIMITED | Unitedkingdom | Billingham | Billingham Complex | Stockton-on-tees | TS23 1PY | cffertilisers.***** | 2016 | $283,645,115 | 255 | N/A | N/A | N/A |
| 88 | Norbrook Holdings LIMITED | Unitedkingdom | Market Harborough | Unit 6 | Leicestershire | LE16 8HB | N/A | 1988 | $281,924,864 | 1,719 | N/A | N/A | N/A |
| 89 | Sandoz LIMITED | Unitedkingdom | Bracknell | Maxis 1 | Bracknell Forest | RG12 1RF | sandoz.***** | 1981 | $279,044,389 | 118 | N/A | N/A | N/A |
| 90 | Sabic UK Petrochemicals LIMITED | Unitedkingdom | Redcar | The Wilton Centre | Redcar and Cleveland | TS10 4RF | huntsman.***** | 1976 | $276,708,570 | 359 | N/A | N/A | N/A |
| 91 | Kiniksa Pharmaceuticals (UK), LTD. | Unitedkingdom | Marylebone | Third Floor | London | W1S 4PZ | N/A | 2018 | $271,258,750 | 209 | N/A | N/A | N/A |
| 92 | Crown Paints LIMITED | Unitedkingdom | Darwen | Crown House | Blackburn With Darwen | BB3 0BJ | crowndecoratingcentre.***** | 2008 | $266,900,373 | 1,069 | N/A | N/A | N/A |
| 93 | Vivergo Fuels LIMITED | Unitedkingdom | Paull | Hedon Road | East Riding of Yorkshire | HU12 8DS | vivergofuels.***** | 2006 | $262,085,197 | 141 | N/A | N/A | N/A |
| 94 | Thornton & Ross LIMITED | Unitedkingdom | Slaithwaite | Linthwaite Labs, Manchester Road | Kirklees, West Yorkshire | HD7 5QH | thorntonandross.***** | 1922 | $259,380,414 | 701 | N/A | N/A | N/A |
| 95 | Vwr International LTD | Unitedkingdom | Lutterworth | Hunter Boulevard | Leicestershire | LE17 4XN | vwr.***** | 1985 | $259,357,596 | 441 | N/A | N/A | N/A |
| 96 | Church & Dwight UK LIMITED | Unitedkingdom | Newington | Bowles Well Gardens | Kent | CT19 6PQ | churchdwight.***** | 1942 | $258,846,720 | 460 | N/A | N/A | N/A |
| 97 | Procter & Gamble Product Supply (U.K.) LIMITED | Unitedkingdom | Weybridge | The Heights | Surrey | KT13 0XP | pandg.***** | 1995 | $258,237,867 | 953 | N/A | N/A | N/A |
| 98 | Reckitt Benckiser Healthcare International LIMITED | Unitedkingdom | Nottingham | D95 Building | Nottingham | NG90 1BS | reckittbenckiser.***** | 1992 | $258,236,965 | 764 | N/A | N/A | N/A |
| 99 | Astellas Pharma LTD. | Unitedkingdom | Byfleet | 68 Chertsey Road | Surrey | GU21 5BJ | astellas.***** | 1990 | $255,724,308 | 111 | N/A | N/A | N/A |
| 100 | Fujifilm Diosynth Biotechnologies UK LIMITED | Unitedkingdom | Billingham | New Billingham House | Stockton-on-tees | TS23 1LH | fujifilmdiosynth.***** | 1970 | $255,147,475 | 991 | N/A | N/A | N/A |